diff --git a/vr180_matting/sam2_wrapper.py b/vr180_matting/sam2_wrapper.py
index 64a37d0..ccb4b34 100644
--- a/vr180_matting/sam2_wrapper.py
+++ b/vr180_matting/sam2_wrapper.py
@@ -49,8 +49,8 @@ class SAM2VideoMatting:
     
     def _load_model(self, model_cfg: str, checkpoint_path: str):
         """Load SAM2 video predictor lazily"""
-        if self._model_loaded:
-            return  # Already loaded
+        if self._model_loaded and self.predictor is not None:
+            return  # Already loaded and predictor exists
             
         try:
             # Import heavy SAM2 modules only when needed
@@ -419,6 +419,9 @@ class SAM2VideoMatting:
             finally:
                 self.predictor = None
         
+        # Reset model loaded state for fresh reload
+        self._model_loaded = False
+        
         # Force garbage collection (critical for memory leak prevention)
         gc.collect()
     
diff --git a/vr180_matting/vr180_processor.py b/vr180_matting/vr180_processor.py
index 738299b..1292056 100644
--- a/vr180_matting/vr180_processor.py
+++ b/vr180_matting/vr180_processor.py
@@ -3,6 +3,7 @@ import numpy as np
 from typing import List, Dict, Any, Optional, Tuple
 from pathlib import Path
 import warnings
+import torch
 
 from .video_processor import VideoProcessor
 from .config import VR180Config
@@ -212,6 +213,10 @@ class VR180Processor(VideoProcessor):
         del right_matted
         self._aggressive_memory_cleanup(f"After combining frames chunk {chunk_idx}")
         
+        # CRITICAL: Complete inter-chunk cleanup to prevent model persistence
+        # This ensures models don't accumulate between chunks
+        self._complete_inter_chunk_cleanup(chunk_idx)
+        
         return combined_frames
     
     def _process_eye_sequence(self, 
@@ -691,6 +696,64 @@ class VR180Processor(VideoProcessor):
         # TODO: Implement proper stereo correction algorithm
         return right_frame
     
+    def _complete_inter_chunk_cleanup(self, chunk_idx: int):
+        """
+        Complete inter-chunk cleanup: Destroy all models to prevent memory accumulation
+        
+        This addresses the core issue where SAM2 and YOLO models (~15-20GB) 
+        persist between chunks, causing OOM when processing subsequent chunks.
+        """
+        print(f"🧹 INTER-CHUNK CLEANUP: Destroying all models after chunk {chunk_idx}")
+        
+        # 1. Completely destroy SAM2 model (15-20GB)
+        if hasattr(self, 'sam2_model') and self.sam2_model is not None:
+            self.sam2_model.cleanup()  # Call existing cleanup
+            
+            # Force complete destruction of the model
+            try:
+                # Reset the model's loaded state so it will reload fresh
+                if hasattr(self.sam2_model, '_model_loaded'):
+                    self.sam2_model._model_loaded = False
+                
+                # Clear any cached state
+                if hasattr(self.sam2_model, 'predictor'):
+                    self.sam2_model.predictor = None
+                if hasattr(self.sam2_model, 'inference_state'):
+                    self.sam2_model.inference_state = None
+                
+                print(f"   ✅ SAM2 model destroyed and marked for fresh reload")
+                
+            except Exception as e:
+                print(f"   ⚠️  SAM2 destruction warning: {e}")
+        
+        # 2. Completely destroy YOLO detector (400MB+)
+        if hasattr(self, 'detector') and self.detector is not None:
+            try:
+                # Force YOLO model to be reloaded fresh
+                if hasattr(self.detector, 'model') and self.detector.model is not None:
+                    del self.detector.model
+                    self.detector.model = None
+                    print(f"   ✅ YOLO model destroyed and marked for fresh reload")
+                    
+            except Exception as e:
+                print(f"   ⚠️  YOLO destruction warning: {e}")
+        
+        # 3. Clear CUDA cache aggressively
+        if torch.cuda.is_available():
+            torch.cuda.empty_cache()
+            torch.cuda.synchronize()  # Wait for all operations to complete
+            print(f"   ✅ CUDA cache cleared")
+        
+        # 4. Force garbage collection
+        import gc
+        collected = gc.collect()
+        print(f"   ✅ Garbage collection: {collected} objects freed")
+        
+        # 5. Memory verification
+        self._print_memory_step(f"After complete inter-chunk cleanup (chunk {chunk_idx})")
+        
+        print(f"🎯 RESULT: Models will reload fresh for next chunk (prevents 15-20GB accumulation)")
+    
     def process_chunk(self, 
                      frames: List[np.ndarray], 
                      chunk_idx: int = 0) -> List[np.ndarray]:
@@ -750,6 +813,9 @@ class VR180Processor(VideoProcessor):
                 combined = {'left': left_frame, 'right': right_frame}
             combined_frames.append(combined)
         
+        # CRITICAL: Complete inter-chunk cleanup for independent processing too
+        self._complete_inter_chunk_cleanup(chunk_idx)
+        
         return combined_frames
     
     def save_video(self, frames: List[np.ndarray], output_path: str):